Regenerative Medicine has been a recent clinical utility in addressing the unmet need in cartilage injury. There has been recent significant clinical and basic science advances in technology and delivery strategy in the last few years. This proposal has brought together leading experts to discuss these advances across multiple domains that include stem cell derived therapies, autologous blood derived therapies and gene transfer strategies. 1: Introductory Lecture: Will focus on terminology in regenerative medicine to allow for a more informed understanding of recent advances from our panel.2: Adipose Derived Therapy : Dr. Malanga is a world leader and authority in stem cell derived therapy and will share his data and recent advances in adipose derived mesenchymal therapy.3: PRP/ Prolotherapy/ Bone Marrow Derived Therapy: Dr. Mautner is an authority in this topic and will discuss recent literature and share clinical results of bone marrow derived cell therapy in cartilage disorders4. Genetic Strategies: Dr. Smith is at the leading front in regenerative medicine and is part of a team at Mayo Clinic that is working towards restoring cartilage injury through gene transfer strategies.