Cardiopulmonary complications of cancer and cancer therapy affect a large portion of survivors and, combined with pre-existing conditions, such as coronary artery disease and pulmonary problems, can result in a significant functional decline. In the first part of the session, we will review the causes of cancer and treatment-related cardiopulmonary morbidity, the scope of the problem, and management strategies across the care continuum. The second part of the session will be dedicated to specific exercise personalization strategies and the use of novel technology, such as telerehabilitation, in the cardiac rehabilitation of cancer survivors. The third part of the session will focus on the role of lactate in cancer metabolism, physical deconditioning and the role of exercise in potentially slowing down cancer growth and recurrence.