More than half the states in the U.S. have approved Cannabis for Medical use, with exponential growth noted in recent years. Modern research suggests that Cannabis is a valuable aid in the treatment of a wide range of clinical applications. These include pain relief, particularly neuropathic pain, nausea, spasticity, and movement disorders. Cannabis has complex properties that provide analgesia, muscle relaxation, appetite stimulation, and sleep induction, which are extremely valuable in the management of neurodegenerative disease, chronic pain, and cancer. Physiatrists involved in a variety of clinical practice settings around the country, will share therapeutic insights regarding the use of Medical Cannabis in the treatment of these conditions, and provide practical regulatory guidelines for its implementation.